Version 5.4
Homo sapiens Gene: BCL7A
Summary
InnateDB Gene IDBG-62116.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL7A
Gene Name B-cell CLL/lymphoma 7A
Synonyms BCL7
Species Homo sapiens
Ensembl Gene ENSG00000110987
Encoded Proteins
IDBP-62118
B-cell CLL/lymphoma 7A
IDBP-589047
B-cell CLL/lymphoma 7A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:122019422-122062044
Strand Forward strand
Band q24.31
Transcripts
ENST00000261822 ENSP00000261822
ENST00000432926
ENST00000538010 ENSP00000445868
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029438
View Gene Order
ENSBTAG00000032517
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q4VC05
TrEMBL
UniProt Splice Variant
Entrez Gene 605
UniGene Hs.530970
RefSeq NM_001024808 NM_020993
HUGO HGNC:1004
OMIM 601406
CCDS CCDS53841 CCDS9226
HPRD
IMGT
EMBL AK296159 AK316486 BC094723 BC113627 CH471054 X89984
GenPept AAH94723 AAI13628 BAG58898 BAH14857 CAA62011 EAW98302
RNA Seq Atlas 605

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca