InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MME

Summary

InnateDB Gene

IDBG-62119.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MME

Gene Name

membrane metallo-endopeptidase

Synonyms

CALLA; CD10; NEP; SFE

Species

Homo sapiens

Ensembl Gene

ENSG00000196549

Encoded Proteins

IDBP-62121

membrane metallo-endopeptidase

IDBP-62123

membrane metallo-endopeptidase

IDBP-476589

membrane metallo-endopeptidase

IDBP-477635

membrane metallo-endopeptidase

IDBP-482970

membrane metallo-endopeptidase

IDBP-474001

membrane metallo-endopeptidase

IDBP-484457

membrane metallo-endopeptidase

IDBP-475996

membrane metallo-endopeptidase

IDBP-475009

membrane metallo-endopeptidase

IDBP-485273

membrane metallo-endopeptidase

IDBP-478610

membrane metallo-endopeptidase

IDBP-813745

membrane metallo-endopeptidase

IDBP-813746

membrane metallo-endopeptidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85%% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5\' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:155024124-155183729

Strand

Forward strand

Band

q25.2

Transcripts

ENST00000360490	ENSP00000353679
ENST00000382989	ENSP00000372450
ENST00000492661	ENSP00000420389
ENST00000460393	ENSP00000418525
ENST00000491597
ENST00000481828	ENSP00000420101
ENST00000462745	ENSP00000419653
ENST00000493237	ENSP00000417079
ENST00000491026	ENSP00000418791
ENST00000473730	ENSP00000420542
ENST00000497890	ENSP00000418238
ENST00000462837	ENSP00000417595
ENST00000477669
ENST00000495577
ENST00000493888
ENST00000615825	ENSP00000478173
ENST00000616757	ENSP00000480349

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	84 [view]
Protein-Protein	83 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008270	zinc ion binding
GO:0042277	peptide binding

Biological Process

GO:0001822	kidney development
GO:0002003	angiotensin maturation
GO:0006508	proteolysis
GO:0006518	peptide metabolic process
GO:0019233	sensory perception of pain
GO:0044267	cellular protein metabolic process
GO:0046449	creatinine metabolic process
GO:0050435	beta-amyloid metabolic process
GO:0071345	cellular response to cytokine stimulus
GO:0071492	cellular response to UV-A
GO:0071493	cellular response to UV-B
GO:0090399	replicative senescence

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005903	brush border
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0044306	neuron projection terminus
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027820

View Gene Order

ENSBTAG00000002075

Not yet available

Pathways

NETPATH

REACTOME

REACT_147707

Metabolism of Angiotensinogen to Angiotensins pathway

REACT_17015

Metabolism of proteins pathway

REACT_160078

Peptide hormone metabolism pathway

KEGG

hsa04614

Renin-angiotensin system pathway

hsa04640

Hematopoietic cell lineage pathway

hsa05010

Alzheimer's disease pathway

hsa04974

Protein digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.307734 Hs.616835

RefSeq

NM_000902 NM_007287 NM_007288 NM_007289 XM_006713646 XM_006713647

HUGO

OMIM

CCDS

CCDS3172

HPRD

00392

IMGT

EMBL

GenPept

RNA Seq Atlas