Version 5.4
Homo sapiens Gene: B3GNT4
Summary
InnateDB Gene IDBG-62254.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol B3GNT4
Gene Name UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000176383
Encoded Proteins
IDBP-62256
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
IDBP-585638
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
IDBP-588248
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase protein family. The encoded enzyme is involved in the biosynthesis of poly-N-acetyllactosamine chains and prefers lacto-N-neotetraose as a substrate. It is a type II transmembrane protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:122203543-122208952
Strand Forward strand
Band q24.31
Transcripts
ENST00000324189 ENSP00000319636
ENST00000546192 ENSP00000438840
ENST00000545141
ENST00000537991
ENST00000538257
ENST00000535274 ENSP00000444534
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008378 galactosyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0016266 O-glycan processing
GO:0018146 keratan sulfate biosynthetic process
GO:0030203 glycosaminoglycan metabolic process
GO:0042339 keratan sulfate metabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029431
View Gene Order
ENSBTAG00000004197
Not yet available
Pathways
NETPATH
REACTOME
REACT_115606
O-linked glycosylation of mucins pathway
REACT_121120
Keratan sulfate biosynthesis pathway
REACT_147853
Mucopolysaccharidoses pathway
REACT_22161
Post-translational protein modification pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_267711
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_267713
Defective CHST6 causes MCDC1 pathway
REACT_121288
Keratan sulfate/keratin metabolism pathway
REACT_147719
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_267645
Defective PAPSS2 causes SEMD-PA pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_147749
MPS IIID - Sanfilippo syndrome D pathway
REACT_267662
Defective SLC26A2 causes chondrodysplasias pathway
REACT_200727
O-linked glycosylation pathway
REACT_147739
MPS IX - Natowicz syndrome pathway
REACT_267674
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_17015
Metabolism of proteins pathway
REACT_267642
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_147798
MPS IV - Morquio syndrome B pathway
REACT_267659
Defective B3GAT3 causes JDSSDHD pathway
REACT_267708
Defective CHST3 causes SEDCJD pathway
REACT_147825
MPS IV - Morquio syndrome A pathway
REACT_267654
Defective EXT2 causes exostoses 2 pathway
REACT_267707
Diseases associated with glycosaminoglycan metabolism pathway
REACT_147734
MPS II - Hunter syndrome pathway
REACT_267635
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_121315
Glycosaminoglycan metabolism pathway
REACT_267705
Diseases of glycosylation pathway
REACT_147759
MPS VII - Sly syndrome pathway
REACT_267682
Defective CHSY1 causes TPBS pathway
REACT_111217
Metabolism pathway
REACT_147857
MPS I - Hurler syndrome pathway
REACT_147753
MPS IIIA - Sanfilippo syndrome A pathway
REACT_147860
MPS IIIC - Sanfilippo syndrome C pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_147788
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
hsa00601
Glycosphingolipid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q9C0J1
TrEMBL A0A024RBT1
UniProt Splice Variant
Entrez Gene 79369
UniGene Hs.363315
RefSeq NM_030765
HUGO HGNC:15683
OMIM 605864
CCDS CCDS9227
HPRD 12058
IMGT
EMBL AB049586 AF321825 AJ130848 AJ278962 AK095746 AL834452 AY358940 BC031399 CH471054
GenPept AAH31399 AAL37219 AAQ89299 BAB21532 BAC04622 CAC45045 CAC82375 CAD39112 EAW98308 EAW98309
RNA Seq Atlas 79369

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca