InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CNOT6

Summary

InnateDB Gene

IDBG-62304.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNOT6

Gene Name

CCR4-NOT transcription complex, subunit 6

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000113300

Encoded Proteins

IDBP-62306

CCR4-NOT transcription complex, subunit 6

IDBP-243782

CCR4-NOT transcription complex, subunit 6

IDBP-475887

CCR4-NOT transcription complex, subunit 6

IDBP-811783

CCR4-NOT transcription complex, subunit 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substates. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:180494412-180578405

Strand

Forward strand

Band

q35.3

Transcripts

ENST00000261951	ENSP00000261951
ENST00000393356	ENSP00000377024
ENST00000510148
ENST00000507016
ENST00000502447
ENST00000504343	ENSP00000422087
ENST00000618123	ENSP00000481893

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004532	exoribonuclease activity
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006417	regulation of translation
GO:0008284	positive regulation of cell proliferation
GO:0010467	gene expression
GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0035195	gene silencing by miRNA
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane
GO:0030014	CCR4-NOT complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020362

View Gene Order

ENSBTAG00000017362

Not yet available

Pathways

NETPATH

REACTOME

REACT_20514

Deadenylation of mRNA pathway

REACT_20639

Deadenylation-dependent mRNA decay pathway

REACT_71

Gene Expression pathway

KEGG

hsa03018

RNA degradation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.608380 Hs.694299 Hs.723528

RefSeq

NM_015455 XM_005265953 XM_006714899 XM_006714900

HUGO

OMIM

CCDS

CCDS4455

HPRD

12341

IMGT

EMBL

GenPept

RNA Seq Atlas