InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNOT6

Summary

InnateDB Protein

IDBP-62306.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNOT6

Protein Name

CCR4-NOT transcription complex, subunit 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261951

InnateDB Gene

IDBG-62304 (CNOT6)

Protein Structure

UniProt Annotation

Function

Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein- coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269PubMed:11889047, ECO:0000269PubMed:18180299, ECO:0000269PubMed:20065043, ECO:0000269PubMed:21233283}.

Subcellular Localization

Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004532	exoribonuclease activity
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006417	regulation of translation
GO:0008284	positive regulation of cell proliferation
GO:0010467	gene expression
GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0035195	gene silencing by miRNA
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity