Version 5.4
Homo sapiens Gene: HRC
Summary
InnateDB Gene IDBG-62366.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HRC
Gene Name histidine rich calcium binding protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130528
Encoded Proteins
IDBP-62368
histidine rich calcium binding protein
IDBP-765534
IDBP-762041
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49151198-49155424
Strand Reverse strand
Band q13.33
Transcripts
ENST00000252825 ENSP00000252825
ENST00000598858 ENSP00000469659
ENST00000595167
ENST00000595625 ENSP00000470288
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0044325 ion channel binding
GO:0051117 ATPase binding
Biological Process
GO:0006936 muscle contraction
GO:0008016 regulation of heart contraction
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0055074 calcium ion homeostasis
Cellular Component
GO:0033017 sarcoplasmic reticulum membrane
GO:0033018 sarcoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038239
View Gene Order
ENSBTAG00000002853
Not yet available
Cross-References
SwissProt P23327
TrEMBL
UniProt Splice Variant
Entrez Gene 3270
UniGene Hs.436885
RefSeq NM_002152
HUGO HGNC:5178
OMIM 142705
CCDS CCDS12759
HPRD 00818
IMGT
EMBL BC069795 BC069802 BC094691 M60052
GenPept AAA88071 AAH69795 AAH69802 AAH94691
RNA Seq Atlas 3270

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca