Version 5.4
Homo sapiens Protein: HRC
Summary
InnateDB Protein IDBP-62368.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HRC
Protein Name histidine rich calcium binding protein
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000252825
InnateDB Gene IDBG-62366 (HRC)
Protein Structure
UniProt Annotation
Function May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.
Subcellular Localization Sarcoplasmic reticulum lumen.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0044325 ion channel binding
GO:0051117 ATPase binding
Biological Process
GO:0006936 muscle contraction
GO:0008016 regulation of heart contraction
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0055074 calcium ion homeostasis
Cellular Component
GO:0033017 sarcoplasmic reticulum membrane
GO:0033018 sarcoplasmic reticulum lumen
Protein Structure and Domains
PDB ID
InterPro IPR019552 Histidine-rich calcium-binding
PFAM PF10529
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23327
PhosphoSite PhosphoSite-P23327
TrEMBL
UniProt Splice Variant
Entrez Gene 3270
UniGene Hs.436885
RefSeq NP_002143
HUGO HGNC:5178
OMIM 142705
CCDS CCDS12759
HPRD 00818
IMGT
EMBL BC069795 BC069802 BC094691 M60052
GenPept AAA88071 AAH69795 AAH69802 AAH94691

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca