Version 5.4
Homo sapiens Gene: NADSYN1
Summary
InnateDB Gene IDBG-62591.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NADSYN1
Gene Name NAD synthetase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172890
Encoded Proteins
IDBP-62593
NAD synthetase 1
IDBP-603842
NAD synthetase 1
IDBP-585226
NAD synthetase 1
IDBP-587749
NAD synthetase 1
IDBP-590709
NAD synthetase 1
IDBP-600510
NAD synthetase 1
IDBP-593217
NAD synthetase 1
IDBP-594081
NAD synthetase 1
IDBP-587953
NAD synthetase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:71453109-71524107
Strand Forward strand
Band q13.4
Transcripts
ENST00000319023 ENSP00000326424
ENST00000534634
ENST00000533612
ENST00000529120 ENSP00000437220
ENST00000528509 ENSP00000433472
ENST00000524949
ENST00000533769
ENST00000527538
ENST00000525245
ENST00000525200 ENSP00000432129
ENST00000530534
ENST00000527852 ENSP00000431515
ENST00000529840 ENSP00000437172
ENST00000530055 ENSP00000431820
ENST00000526039
ENST00000527227
ENST00000531236
ENST00000524450
ENST00000530831
ENST00000525593 ENSP00000433612
ENST00000527963 ENSP00000435570
ENST00000528211
ENST00000624637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity
GO:0005524 ATP binding
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Biological Process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0009435 NAD biosynthetic process
GO:0019674 NAD metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031090
View Gene Order
ENSBTAG00000016470
Not yet available
Pathways
NETPATH
REACTOME
REACT_11088
Nicotinate metabolism pathway
REACT_169312
Defective HLCS causes multiple carboxylase deficiency pathway
REACT_169313
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_169316
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_169120
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_11238
Metabolism of water-soluble vitamins and cofactors pathway
REACT_169280
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_169149
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_169363
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_169178
Defective CD320 causes methylmalonic aciduria pathway
REACT_169429
Defects in cobalamin (B12) metabolism pathway
REACT_169169
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_169238
Defects in biotin (Btn) metabolism pathway
REACT_169403
Defective BTD causes biotidinase deficiency pathway
REACT_169415
Defective GIF causes intrinsic factor deficiency pathway
REACT_169385
Defects in vitamin and cofactor metabolism pathway
REACT_169132
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_169256
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_169439
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_111217
Metabolism pathway
REACT_169318
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_116125
Disease pathway
REACT_11193
Metabolism of vitamins and cofactors pathway
KEGG
hsa00760
Nicotinate and nicotinamide metabolism pathway
INOH
INOH website
Nicotinate Nicotinamide metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.556986 Hs.639513 Hs.722030 Hs.738814
RefSeq NM_018161
HUGO
OMIM
CCDS CCDS8201
HPRD 16309
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca