InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC17A7

Summary

InnateDB Gene

IDBG-62636.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC17A7

Gene Name

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000104888

Encoded Proteins

IDBP-62638

solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7

IDBP-763090

IDBP-759844

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:49429401-49442360

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000221485	ENSP00000221485
ENST00000600672
ENST00000600601	ENSP00000470338
ENST00000598018
ENST00000596689	ENSP00000472086

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005313	L-glutamate transmembrane transporter activity
GO:0005315	inorganic phosphate transmembrane transporter activity
GO:0015319	sodium:inorganic phosphate symporter activity
GO:0015321	sodium-dependent phosphate transmembrane transporter activity

Biological Process

GO:0006811	ion transport
GO:0006817	phosphate ion transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007616	long-term memory
GO:0014047	glutamate secretion
GO:0035249	synaptic transmission, glutamatergic
GO:0035435	phosphate ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042137	sequestering of neurotransmitter
GO:0044341	sodium-dependent phosphate transport
GO:0051938	L-glutamate import
GO:0055085	transmembrane transport
GO:0060079	regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0043005	neuron projection
GO:0043229	intracellular organelle
GO:0044300	cerebellar mossy fiber
GO:0045202	synapse
GO:0048786	presynaptic active zone
GO:0060076	excitatory synapse
GO:0060203	clathrin-sculpted glutamate transport vesicle membrane