Version 5.4
Homo sapiens Gene: SSR3
Summary
InnateDB Gene IDBG-62665.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SSR3
Gene Name signal sequence receptor, gamma (translocon-associated protein gamma)
Synonyms TRAPG
Species Homo sapiens
Ensembl Gene ENSG00000114850
Encoded Proteins
IDBP-62667
signal sequence receptor, gamma (translocon-associated protein gamma)
IDBP-484698
signal sequence receptor, gamma (translocon-associated protein gamma)
IDBP-481225
signal sequence receptor, gamma (translocon-associated protein gamma)
IDBP-474417
signal sequence receptor, gamma (translocon-associated protein gamma)
IDBP-475610
signal sequence receptor, gamma (translocon-associated protein gamma)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:156540140-156555184
Strand Reverse strand
Band q25.31
Transcripts
ENST00000265044 ENSP00000265044
ENST00000467789 ENSP00000420641
ENST00000476217 ENSP00000417530
ENST00000498205
ENST00000478842
ENST00000464138
ENST00000463503 ENSP00000417306
ENST00000496050 ENSP00000420087
ENST00000467733
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006412 translation
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005784 Sec61 translocon complex
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027828
View Gene Order
ENSBTAG00000018471
Not yet available
Pathways
NETPATH
REACTOME
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_71
Gene Expression pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518346 Hs.603700 Hs.659884 Hs.711838
RefSeq NM_007107
HUGO
OMIM
CCDS CCDS3176
HPRD 16206
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca