Version 5.4
Homo sapiens Gene: DENR
Summary
InnateDB Gene IDBG-62817.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DENR
Gene Name density-regulated protein
Synonyms DRP; DRP1; SMAP-3
Species Homo sapiens
Ensembl Gene ENSG00000139726
Encoded Proteins
IDBP-62819
density-regulated protein
IDBP-384679
density-regulated protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:122752774-122771064
Strand Forward strand
Band q24.31
Transcripts
ENST00000280557 ENSP00000280557
ENST00000455982 ENSP00000413661
ENST00000539463
ENST00000537955
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0002192 IRES-dependent translational initiation
GO:0006413 translational initiation
GO:0008150 biological_process
GO:0032790 ribosome disassembly
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023106
View Gene Order
ENSBTAG00000034850
Not yet available
Cross-References
SwissProt O43583
TrEMBL A0A024RBR3 F8VVL1
UniProt Splice Variant
Entrez Gene 8562
UniGene Hs.22393
RefSeq NM_003677
HUGO HGNC:2769
OMIM 604550
CCDS CCDS45003
HPRD
IMGT
EMBL AB014731 AC026331 AC027290 AF038554 AF103800 BC007860 CH471054
GenPept AAC02985 AAF02420 AAH07860 BAB20268 EAW98338 EAW98342
RNA Seq Atlas 8562

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca