InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DENR

Summary

InnateDB Protein

IDBP-62819.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DENR

Protein Name

density-regulated protein

Synonyms

DRP; DRP1; SMAP-3;

Species

Homo sapiens

Ensembl Protein

ENSP00000280557

InnateDB Gene

IDBG-62817 (DENR)

Protein Structure

UniProt Annotation

Function

May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1. {ECO:0000269PubMed:16982740, ECO:0000269PubMed:17878526, ECO:0000269PubMed:20713520}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney. {ECO:0000269PubMed:9628587}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003743	translation initiation factor activity
GO:0005515	protein binding

Biological Process

GO:0001731	formation of translation preinitiation complex
GO:0002192	IRES-dependent translational initiation
GO:0006413	translational initiation
GO:0008150	biological_process
GO:0032790	ribosome disassembly