Version 5.4
Homo sapiens Gene: JARID2
Summary
InnateDB Gene IDBG-62820.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol JARID2
Gene Name jumonji, AT rich interactive domain 2
Synonyms JMJ
Species Homo sapiens
Ensembl Gene ENSG00000008083
Encoded Proteins
IDBP-62822
jumonji, AT rich interactive domain 2
IDBP-235655
jumonji, AT rich interactive domain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:15246296-15522040
Strand Forward strand
Band p22.3
Transcripts
ENST00000341776 ENSP00000341280
ENST00000397311 ENSP00000380478
ENST00000474854
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 28 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001889 liver development
GO:0006351 transcription, DNA-templated
GO:0007417 central nervous system development
GO:0008285 negative regulation of cell proliferation
GO:0016568 chromatin modification
GO:0031061 negative regulation of histone methylation
GO:0042127 regulation of cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048863 stem cell differentiation
GO:0051574 positive regulation of histone H3-K9 methylation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0035097 histone methyltransferase complex
GO:0035098 ESC/E(Z) complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038518
View Gene Order
ENSBTAG00000012938
Not yet available
Pathways
NETPATH
REACTOME
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.269059 Hs.732973
RefSeq NM_001267040 NM_004973 XM_005249089
HUGO
OMIM
CCDS CCDS4533 CCDS58996
HPRD 03355
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca