InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ACTA1

Summary

InnateDB Gene

IDBG-628380.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTA1

Gene Name

Actin, alpha skeletal muscle

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000046332

Encoded Proteins

IDBP-679734

Actin, alpha skeletal muscle

IDBP-679735

Actin, alpha skeletal muscle

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143632:
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:419154-421910

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000006532	ENSBTAP00000006532
ENSBTAT00000006534	ENSBTAP00000006534

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	80 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0030240	skeletal muscle thin filament assembly
GO:0048741	skeletal muscle fiber development

Cellular Component

GO:0001725	stress fiber
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005865	striated muscle thin filament
GO:0005884	actin filament
GO:0015629	actin cytoskeleton
GO:0030017	sarcomere
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle