InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GALNT2

Summary

InnateDB Gene

IDBG-628390.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GALNT2

Gene Name

polypeptide N-acetylgalactosaminyltransferase 2 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004870

Encoded Proteins

IDBP-679744

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143641:
This gene encodes polypeptide N-acetylgalactosaminyltransferase 2, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation in a cell is regulated by a repertoire of GalNAc-transferases. [provided by RefSeq, Jul 2008]
This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:1126801-1313125

Strand

Forward strand

Band

Transcripts

ENSBTAT00000006404

ENSBTAP00000006404

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0030145	manganese ion binding
GO:0046872	metal ion binding

Biological Process

GO:0002378	immunoglobulin biosynthetic process
GO:0006486	protein glycosylation
GO:0006493	protein O-linked glycosylation
GO:0018242	protein O-linked glycosylation via serine
GO:0018243	protein O-linked glycosylation via threonine

Cellular Component

GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome