InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GALNT2

Summary

InnateDB Gene

IDBG-107346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GALNT2

Gene Name

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)

Synonyms

GalNAc-T2

Species

Homo sapiens

Ensembl Gene

ENSG00000143641

Encoded Proteins

IDBP-107348

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes polypeptide N-acetylgalactosaminyltransferase 2, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation in a cell is regulated by a repertoire of GalNAc-transferases. [provided by RefSeq, Jul 2008]
This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:230057990-230282124

Strand

Forward strand

Band

q42.13

Transcripts

ENST00000366672	ENSP00000355632
ENST00000494106
ENST00000488903
ENST00000485438
ENST00000492568

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity
GO:0030145	manganese ion binding

Biological Process

GO:0002378	immunoglobulin biosynthetic process
GO:0006493	protein O-linked glycosylation
GO:0016266	O-glycan processing
GO:0018242	protein O-linked glycosylation via serine
GO:0018243	protein O-linked glycosylation via threonine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0016020	membrane
GO:0030173	integral component of Golgi membrane
GO:0032580	Golgi cisterna membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000089704

View Gene Order

ENSBTAG00000004870

Not yet available

Pathways

NETPATH

REACTOME

REACT_115606

O-linked glycosylation of mucins pathway

REACT_22161

Post-translational protein modification pathway

REACT_200727

O-linked glycosylation pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa00512

Mucin type O-Glycan biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.654649 Hs.743422

RefSeq

NM_001291866 NM_004481

HUGO

OMIM

CCDS

CCDS1582

HPRD

03782

IMGT

EMBL

GenPept

RNA Seq Atlas