Bos taurus Gene: BT.85182 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-628495.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | BT.85182 | ||||||||||||||||
Gene Name | dual specificity protein phosphatase 1 | ||||||||||||||||
Synonyms | MKP-1 | ||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000013863 | ||||||||||||||||
Encoded Proteins |
dual specificity protein phosphatase 1
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||
Summary |
[Homo sapiens] DUSP1 inhibits MAPK pathways and decreases TLR signalling.
[Homo sapiens] DUSP1 is an essential feedback regulator of the innate immune response, it plays a critical role in preventing septic shock and multi-organ dysfunction during pathogenic infection and plays a pivotal role in the deactivation of MAPK1 and MAPK8.
[Homo sapiens] DUSP1 is a negative regulator of MAPK-dependent induction of IL6 and IL8 in response to the coronavirus infectious bronchitis virus (IBV).
[Homo sapiens] DUSP1 antagonizes p38 MAPK activity to induce IL12B expression, and may play a role in the development of Th1 type immune response and anti-microbial defence. (Demonstrated in mice)
[Mus musculus] Dusp1 is a negative regulator of MAPK-dependent induction of Il6 and Il8 in response to the coronavirus infectious bronchitis virus (IBV). (Demonstrated in human)
[Mus musculus] Dusp1 antagonizes p38 MAPK activity to induce Il12b expression, and may play a role in the development of Th1 type immune response and anti-microbial defence.
[Mus musculus] Dusp1 modulates the phosphorylation status of mRNA-destabilizing protein Zfp36 to regulate macrophage immune response to lipopolysaccharide.
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Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120129:
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008] The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 20:4449109-4452189 | ||||||||||||||||
Strand | Reverse strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH |
EGFR1 pathway
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REACTOME | |||||||||||||||||
KEGG |
MAPK signaling pathway pathway
MAPK signaling pathway pathway
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INOH | |||||||||||||||||
PID NCI |
Direct p53 effectors
ErbB1 downstream signaling
ATF-2 transcription factor network
AP-1 transcription factor network
Regulation of p38-alpha and p38-beta
Fc-epsilon receptor I signaling in mast cells
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Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | F1MI99 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 539175 | ||||||||||||||||
UniGene | Bt.1658 Bt.85182 | ||||||||||||||||
RefSeq | NM_001046452 | ||||||||||||||||
HUGO | |||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | DAAA02049901 | ||||||||||||||||
GenPept | |||||||||||||||||
RNA Seq Atlas | 539175 | ||||||||||||||||