Version 5.4
Bos taurus Gene: SORBS2
Summary
InnateDB Gene IDBG-628561.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SORBS2
Gene Name sorbin and SH3 domain-containing protein 2
Synonyms Argbp2
Species Bos taurus
Ensembl Gene ENSBTAG00000016486
Encoded Proteins
IDBP-679933
sorbin and SH3 domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154556:
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 27:14906506-15022818
Strand Reverse strand
Band
Transcripts
ENSBTAT00000021917 ENSBTAP00000021917
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Predicted by orthology
Total 30 [view]
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000154556
View Gene Order
ENSMUSG00000031626
View Gene Order
Cross-References
SwissProt
TrEMBL A0JN82
UniProt Splice Variant
Entrez Gene 614391
UniGene Bt.107524
RefSeq NM_001079787
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126558 DAAA02060197 DAAA02060198
GenPept AAI26559
RNA Seq Atlas 614391

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca