InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: F11

Summary

InnateDB Gene

IDBG-628594.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F11

Gene Name

coagulation factor XI precursor

Synonyms

FXI

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003572

Encoded Proteins

IDBP-679962

coagulation factor XI precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21807745

[Homo sapiens] F11 modulates the inflammatory response of PMN leukocytes by reducing chemotaxis triggered by IL8 or fMLP, highlighting the interplay between inflammation and coagulation (Demonstrated in mouse)

PMID 21807745

[Mus musculus] F11 modulates the inflammatory response of PMN leukocytes by reducing chemotaxis triggered by Il8 or fMLP, highlighting the interplay between inflammation and coagulation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088926:
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 27:15350931-15370080

Strand

Forward strand

Band

Transcripts

ENSBTAT00000004648

ENSBTAP00000004648

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0030193	regulation of blood coagulation
GO:0031639	plasminogen activation
GO:0051919	positive regulation of fibrinolysis