InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: F11

Summary

InnateDB Gene

IDBG-47627.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F11

Gene Name

coagulation factor XI

Synonyms

FXI

Species

Homo sapiens

Ensembl Gene

ENSG00000088926

Encoded Proteins

IDBP-47629

coagulation factor XI

IDBP-47631

coagulation factor XI

IDBP-294810

coagulation factor XI

IDBP-380901

coagulation factor XI

IDBP-475938

coagulation factor XI

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21807745

F11 modulates the inflammatory response of PMN leukocytes by reducing chemotaxis triggered by IL8 or fMLP, highlighting the interplay between inflammation and coagulation (Demonstrated in mouse)

InnateDB Annotation from Orthologs

Summary

PMID 21807745

[Mus musculus] F11 modulates the inflammatory response of PMN leukocytes by reducing chemotaxis triggered by Il8 or fMLP, highlighting the interplay between inflammation and coagulation.

Entrez Gene

Summary

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:186265945-186288806

Strand

Forward strand

Band

q35.2

Transcripts

ENST00000264691	ENSP00000264691
ENST00000264692	ENSP00000264692
ENST00000403665	ENSP00000384957
ENST00000452239	ENSP00000397401
ENST00000492972	ENSP00000424479
ENST00000514715
ENST00000503841

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0070009	serine-type aminopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0030193	regulation of blood coagulation
GO:0031639	plasminogen activation
GO:0045087	innate immune response (InnateDB)
GO:0051919	positive regulation of fibrinolysis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031645

View Gene Order

ENSBTAG00000003572

Not yet available

Pathways

NETPATH

REACTOME

REACT_326

Intrinsic Pathway pathway

REACT_2051

Formation of Fibrin Clot (Clotting Cascade) pathway

REACT_604

Hemostasis pathway

KEGG

hsa04610

Complement and coagulation cascades pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q9UEG0

UniProt Splice Variant

Entrez Gene

2160

UniGene

RefSeq

NM_000128 XM_005262821 XM_005262824 XM_005262825

HUGO

HGNC:3529

OMIM

264900

CCDS

CCDS3847

HPRD

07524

IMGT

EMBL

AB004057

GenPept

BAA20295

RNA Seq Atlas

2160