Version 5.4
Bos taurus Gene: MEF2A
Summary
InnateDB Gene IDBG-628642.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEF2A
Gene Name Myocyte-specific enhancer factor 2A
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010649
Encoded Proteins
IDBP-680011
Myocyte-specific enhancer factor 2A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068305:
The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:7045098-7225412
Strand Reverse strand
Band
Transcripts
ENSBTAT00000014074 ENSBTAP00000014074
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085 RNA polymerase II transcription factor binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0033613 activating transcription factor binding
GO:0035035 histone acetyltransferase binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0007275 multicellular organismal development
GO:0007399 nervous system development
GO:0007507 heart development
GO:0030154 cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048311 mitochondrion distribution
GO:0048813 dendrite morphogenesis
GO:0055005 ventricular cardiac myofibril assembly
GO:0061337 cardiac conduction
GO:0070375 ERK5 cascade
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000068305
View Gene Order
ENSMUSG00000030557
View Gene Order
Pathways
NETPATH
REACTOME
REACT_218237
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_210286
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_216172
Myogenesis pathway
REACT_224703
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_205566
Activated TLR4 signalling pathway
REACT_222278
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_224546
MyD88-independent cascade pathway
REACT_217035
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_227345
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_210224
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_213138
Immune System pathway
REACT_227036
MAP kinase activation in TLR cascade pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_214353
Signal Transduction pathway
REACT_210416
Nuclear Events (kinase and transcription factor activation) pathway
REACT_223848
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_225653
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_218091
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_207066
Signalling by NGF pathway
REACT_226850
ERK/MAPK targets pathway
REACT_216676
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_219586
MyD88 dependent cascade initiated on endosome pathway
REACT_216456
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_207559
CDO in myogenesis pathway
REACT_216714
Innate Immune System pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_217527
MyD88 cascade initiated on plasma membrane pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_12599
ERK/MAPK targets pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_21402
CDO in myogenesis pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_111102
Signal Transduction pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_21303
Myogenesis pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_12433
Nuclear Events (kinase and transcription factor activation) pathway
REACT_21328
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_229712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_210065
MAPK targets/ Nuclear events mediated by MAP kinases pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_215063
ERK/MAPK targets pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_262171
MAP kinase activation in TLR cascade pathway
REACT_230745
Immune System pathway
REACT_253473
Myogenesis pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_258600
CDO in myogenesis pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_256727
MyD88 dependent cascade initiated on endosome pathway
REACT_248921
Signalling by NGF pathway
REACT_188576
Developmental Biology pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_241786
MyD88-independent cascade pathway
REACT_188257
Signal Transduction pathway
REACT_242921
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_222431
Nuclear Events (kinase and transcription factor activation) pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
INOH
PID NCI
p38alphabetadownstreampathway
Signaling mediated by p38-alpha and p38-beta
Cross-References
SwissProt A2VDZ3
TrEMBL D2KFG0 G9JVE0 Q6WZC9
UniProt Splice Variant
Entrez Gene 407231
UniGene Bt.25066 Bt.68658 Bt.73950
RefSeq NM_001083638
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY263350 BC133487 GU211006 JN944535 JN944536
GenPept AAI33488 AAR12638 ACZ72604 AEW22945 AEW22946
RNA Seq Atlas 407231

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca