InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MEF2A

Summary

InnateDB Protein

IDBP-680011.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MEF2A

Protein Name

Myocyte-specific enhancer factor 2A

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000014074

InnateDB Gene

IDBG-628642 (MEF2A)

Protein Structure

UniProt Annotation

Function

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00251}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0033613	activating transcription factor binding
GO:0035035	histone acetyltransferase binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0046332	SMAD binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000002	mitochondrial genome maintenance
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000165	MAPK cascade
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0007507	heart development
GO:0030154	cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048311	mitochondrion distribution
GO:0048813	dendrite morphogenesis
GO:0055005	ventricular cardiac myofibril assembly
GO:0061337	cardiac conduction
GO:0070375	ERK5 cascade
GO:0071277	cellular response to calcium ion

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002100 Transcription factor, MADS-box
IPR022102 Holliday junction regulator protein family C-terminal

PFAM

PF00319
PF12347

PRINTS

PR00404

PIRSF

SMART

SM00432

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A2VDZ3

PhosphoSite

PhosphoSite-

TrEMBL

Q6WZC9

UniProt Splice Variant

Entrez Gene

407231

UniGene

Bt.73950

RefSeq

NP_001077107

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY263350 BC133487 GU211006 JN944535 JN944536

GenPept

AAI33488 AAR12638 ACZ72604 AEW22945 AEW22946