Version 5.4
Bos taurus Gene: MTRF1
Summary
InnateDB Gene IDBG-628652.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTRF1
Gene Name Peptide chain release factor 1, mitochondrial
Synonyms MtRF-1
Species Bos taurus
Ensembl Gene ENSBTAG00000012260
Encoded Proteins
IDBP-680021
Peptide chain release factor 1, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120662:
The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:11452445-11494158
Strand Reverse strand
Band
Transcripts
ENSBTAT00000016261 ENSBTAP00000016261
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003747 translation release factor activity
GO:0016149 translation release factor activity, codon specific
Biological Process
GO:0006412 translation
GO:0006415 translational termination
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000120662
View Gene Order
ENSMUSG00000022022
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_267673
Mitochondrial translation pathway
REACT_267602
Mitochondrial translation termination pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q3MHI7
TrEMBL
UniProt Splice Variant
Entrez Gene 504754
UniGene Bt.37767
RefSeq NM_001035013 XM_005213564 XM_005213565 XM_005213566
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105224
GenPept AAI05225
RNA Seq Atlas 504754

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca