Version 5.4
| Bos taurus Gene: HLA-DMB | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-628872.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | HLA-DMB | ||||||||
| Gene Name | major histocompatibility complex, class II, DM beta precursor | ||||||||
| Synonyms | DMB | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000012451 | ||||||||
| Encoded Proteins |
HLA class II histocompatibility antigen, DM beta chain
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000242574:
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 23:7186801-7193645 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Mus musculus
Homo sapiens
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
MHC class II antigen presentation pathway
Adaptive Immune System pathway
Immune System pathway
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| KEGG |
Cell adhesion molecules (CAMs) pathway
Type I diabetes mellitus pathway
Antigen processing and presentation pathway
Asthma pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Systemic lupus erythematosus pathway
Autoimmune thyroid disease pathway
Intestinal immune network for IgA production pathway
Viral myocarditis pathway
Staphylococcus aureus infection pathway
Leishmaniasis pathway
Phagosome pathway
Toxoplasmosis pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Type I diabetes mellitus pathway
Allograft rejection pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Graft-versus-host disease pathway
Asthma pathway
Intestinal immune network for IgA production pathway
Viral myocarditis pathway
Leishmaniasis pathway
Staphylococcus aureus infection pathway
Toxoplasmosis pathway
Phagosome pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | Q30262 Q58DW7 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 282491 | ||||||||
| UniGene | Bt.1007 | ||||||||
| RefSeq | NM_001040481 XM_005223197 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AY957499 BC118361 BT021480 D76417 DAAA02054879 | ||||||||
| GenPept | AAI18362 AAX46327 AAY34701 BAA11172 | ||||||||
| RNA Seq Atlas | 282491 | ||||||||