Version 5.4
Bos taurus Gene: PDE4D
Summary
InnateDB Gene IDBG-628921.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE4D
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000494
Encoded Proteins
IDBP-680296
phosphodiesterase 4D, cAMP-specific
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113448:
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
This gene encodes one of four mammalian counterparts to the fruit fly \'dunce\' gene. The encoded protein has 3\',5\'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:20268721-20321935
Strand Forward strand
Band
Transcripts
ENSBTAT00000000631 ENSBTAP00000000631
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0008144 drug binding
GO:0016787 hydrolase activity
GO:0030552 cAMP binding
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
GO:0051117 ATPase binding
GO:0097110 scaffold protein binding
Biological Process
GO:0006198 cAMP catabolic process
GO:0006939 smooth muscle contraction
GO:0007165 signal transduction
GO:0007568 aging
GO:0008152 metabolic process
GO:0030593 neutrophil chemotaxis
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0032754 positive regulation of interleukin-5 production
GO:0035264 multicellular organism growth
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0071222 cellular response to lipopolysaccharide
GO:0071320 cellular response to cAMP
GO:0071872 cellular response to epinephrine stimulus
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0034704 calcium channel complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000113448
View Gene Order
ENSMUSG00000021699
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_23
TSH pathway
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_15334
DARPP-32 events pathway
REACT_15295
Opioid Signalling pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_242871
G alpha (s) signalling events pathway
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_203795
DARPP-32 events pathway
REACT_242845
Opioid Signalling pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa00230
Purine metabolism pathway
mmu00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL F1MS27
UniProt Splice Variant
Entrez Gene 539556
UniGene Bt.45184
RefSeq XM_002696315 XM_003583682 XM_003583684 XM_003583686 XM_003583689 XM_003587510 XM_003587511 XM_003587512 XM_003587514 XM_003587517 XM_005196133 XM_005196134 XM_005196135 XM_005196136 XM_005196137 XM_005196138 XM_005221505 XM_005221506 XM_005221507 XM_005221508 XM_005221509 XM_005221510 XM_588063
HUGO HGNC:8783
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02050286 DAAA02050287
GenPept
RNA Seq Atlas 539556

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca