Version 5.4
| Bos taurus Gene: FGA | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-628958.3 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | FGA | ||||||
| Gene Name | fibrinogen alpha chain precursor | ||||||
| Synonyms | |||||||
| Species | Bos taurus | ||||||
| Ensembl Gene | ENSBTAG00000001638 | ||||||
| Encoded Proteins |
fibrinogen alpha chain precursor
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| Protein Structure | |||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171560:
The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 17:2842939-2849702 | ||||||
| Strand | Forward strand | ||||||
| Band | |||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH | |||||||
| REACTOME |
Common Pathway pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Integrin cell surface interactions pathway
Amyloids pathway
Extracellular matrix organization pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Disease pathway
Hemostasis pathway
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| KEGG |
Complement and coagulation cascades pathway
Complement and coagulation cascades pathway
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| INOH | |||||||
| PID NCI |
Beta1 integrin cell surface interactions
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Beta3 integrin cell surface interactions
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| Cross-References | |||||||
| SwissProt | |||||||
| TrEMBL | A5PJE3 B1B3F8 B1B3F9 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 522039 | ||||||
| UniGene | Bt.17997 | ||||||
| RefSeq | NM_001033626 | ||||||
| HUGO | |||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AB300331 AB300332 BC142072 DAAA02044108 | ||||||
| GenPept | AAI42073 BAG12973 BAG12974 | ||||||
| RNA Seq Atlas | 522039 | ||||||