InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fga

Summary

InnateDB Gene

IDBG-154534.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fga

Gene Name

fibrinogen alpha chain

Synonyms

ENSMUSG00000059807; Fib

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028001

Encoded Proteins

IDBP-154536

fibrinogen alpha chain

IDBP-619968

fibrinogen alpha chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171560:
The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:83026153-83033615

Strand

Forward strand

Band

Transcripts

ENSMUST00000029630	ENSMUSP00000029630
ENSMUST00000166581	ENSMUSP00000133117

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0034116	positive regulation of heterotypic cell-cell adhesion
GO:0043623	cellular protein complex assembly
GO:0045907	positive regulation of vasoconstriction
GO:0045921	positive regulation of exocytosis
GO:0050714	positive regulation of protein secretion
GO:0051258	protein polymerization
GO:0051592	response to calcium ion
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070527	platelet aggregation
GO:0072377	blood coagulation, common pathway
GO:0090277	positive regulation of peptide hormone secretion
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0005577	fibrinogen complex
GO:0005615	extracellular space
GO:0005938	cell cortex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0031091	platelet alpha granule
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle