InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BUB1

Summary

InnateDB Gene

IDBG-628990.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BUB1

Gene Name

mitotic checkpoint serine/threonine-protein kinase BUB1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021181

Encoded Proteins

IDBP-680390

mitotic checkpoint serine/threonine-protein kinase BUB1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169679:
This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer. [provided by RefSeq, Jul 2008]
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:1559190-1592162

Strand

Forward strand

Band

Transcripts

ENSBTAT00000028226

ENSBTAP00000028226

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007059	chromosome segregation
GO:0007063	regulation of sister chromatid cohesion
GO:0051983	regulation of chromosome segregation
GO:0071173	spindle assembly checkpoint
GO:0071174	mitotic spindle checkpoint
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane