InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bub1

Summary

InnateDB Gene

IDBG-205152.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bub1

Gene Name

budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)

Synonyms

AL022991; Bub1a; C80208; D2Xrf87

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027379

Encoded Proteins

IDBP-205156

budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169679:
This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer. [provided by RefSeq, Jul 2008]
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:127801122-127831865

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028858	ENSMUSP00000028858
ENSMUST00000138624
ENSMUST00000153048
ENSMUST00000143824
ENSMUST00000133943

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007059	chromosome segregation
GO:0007063	regulation of sister chromatid cohesion
GO:0008283	cell proliferation
GO:0051983	regulation of chromosome segregation
GO:0071173	spindle assembly checkpoint
GO:0071174	mitotic spindle checkpoint
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane