Version 5.4
Bos taurus Gene: MFGE8
Summary
InnateDB Gene IDBG-629001.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MFGE8
Gene Name lactadherin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003300
Encoded Proteins
IDBP-680395
lactadherin
IDBP-680397
lactadherin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23454767
[Mus musculus] MFGE8 inhibits inflammasome-induced IL1B production in macrophages.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140545:
Gene Information
Type Protein coding
Genomic Location Chromosome 21:20889913-20904968
Strand Reverse strand
Band
Transcripts
ENSBTAT00000004272 ENSBTAP00000004272
ENSBTAT00000065341 ENSBTAP00000054756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001786 phosphatidylserine binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008429 phosphatidylethanolamine binding
Biological Process
GO:0006910 phagocytosis, recognition
GO:0006911 phagocytosis, engulfment
GO:0007155 cell adhesion
GO:0050766 positive regulation of phagocytosis
GO:2000427 positive regulation of apoptotic cell clearance
Cellular Component
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0019897 extrinsic component of plasma membrane
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000140545
View Gene Order
ENSMUSG00000030605
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75925
Amyloids pathway
REACT_116125
Disease pathway
REACT_189085
Disease pathway
REACT_198563
Amyloids pathway
KEGG
INOH
PID NCI
avb3_integrin_pathway
Integrins in angiogenesis
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL F1MXX6 G3MYW7
UniProt Splice Variant
Entrez Gene 281913
UniGene Bt.5250
RefSeq NM_176610 XM_005221808
HUGO HGNC:7036
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02052136
GenPept
RNA Seq Atlas 281913

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca