Version 5.4
| Bos taurus Gene: MAP3K1 | |||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||
| InnateDB Gene | IDBG-629015.3 | ||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
| Gene Symbol | MAP3K1 | ||||||||||||||||||||||||||
| Gene Name | mitogen-activated protein kinase kinase kinase 1 | ||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000013790 | ||||||||||||||||||||||||||
| Encoded Proteins |
mitogen-activated protein kinase kinase kinase 1
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| Protein Structure | |||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||
| Summary |
[Homo sapiens] MAP3K1 and TRAF6 play a pivotal role in the retinoic-acid-inducible gene-I (RIG-I)-like helicase antiviral pathway.
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| Entrez Gene | |||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095015:
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012] |
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| Gene Information | |||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||
| Genomic Location | Chromosome 20:22360764-22435963 | ||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 131 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
Wnt pathway
TNFalpha pathway
TCR pathway
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| REACTOME |
TRAF6 mediated NF-kB activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
Immune System pathway
Activated TLR4 signalling pathway
FCERI mediated MAPK activation pathway
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| KEGG |
GnRH signaling pathway pathway
MAPK signaling pathway pathway
Ubiquitin mediated proteolysis pathway
Neurotrophin signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Ubiquitin mediated proteolysis pathway
GnRH signaling pathway pathway
MAPK signaling pathway pathway
Neurotrophin signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
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| INOH |
IL-7 signaling pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
EGF signaling pathway pathway
PDGF signaling pathway pathway
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| PID NCI |
CD40/CD40L signaling
Ceramide signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Caspase Cascade in Apoptosis
TNF receptor signaling pathway
TRAIL signaling pathway
ErbB1 downstream signaling
RAC1 signaling pathway
BCR signaling pathway
JNK signaling in the CD4+ TCR pathway
CDC42 signaling events
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Fc-epsilon receptor I signaling in mast cells
IFN-gamma pathway
Osteopontin-mediated events
FAS (CD95) signaling pathway
p38 MAPK signaling pathway
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| Cross-References | |||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||
| TrEMBL | E1B847 | ||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||
| Entrez Gene | 523962 | ||||||||||||||||||||||||||
| UniGene | Bt.108281 Bt.65484 | ||||||||||||||||||||||||||
| RefSeq | NM_001205906 XM_005221497 XM_005221498 | ||||||||||||||||||||||||||
| HUGO | HGNC:6848 | ||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||
| EMBL | DAAA02050318 | ||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||
| RNA Seq Atlas | 523962 | ||||||||||||||||||||||||||