Mus musculus Gene: Map3k1 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-182342.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | Map3k1 | ||||||||||||||||||||||||||||
Gene Name | mitogen-activated protein kinase kinase kinase 1 | ||||||||||||||||||||||||||||
Synonyms | MAPKKK1; Mekk; MEKK1 | ||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000021754 | ||||||||||||||||||||||||||||
Encoded Proteins |
mitogen-activated protein kinase kinase kinase 1
mitogen-activated protein kinase kinase kinase 1
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Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||
Summary |
[Homo sapiens] MAP3K1 and TRAF6 play a pivotal role in the retinoic-acid-inducible gene-I (RIG-I)-like helicase antiviral pathway.
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Entrez Gene | |||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095015:
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012] |
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Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome 13:111746428-111808993 | ||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||
Band | D2.2 | ||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 105 experimentally validated interaction(s) in this database.
They are also associated with 134 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||||||||
KEGG |
Ubiquitin mediated proteolysis pathway
GnRH signaling pathway pathway
MAPK signaling pathway pathway
Neurotrophin signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
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INOH | |||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||
NETPATH |
EGFR1 pathway
Wnt pathway
TNFalpha pathway
TCR pathway
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REACTOME |
TRAF6 mediated NF-kB activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
Immune System pathway
Activated TLR4 signalling pathway
FCERI mediated MAPK activation pathway
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KEGG |
GnRH signaling pathway pathway
MAPK signaling pathway pathway
Ubiquitin mediated proteolysis pathway
Neurotrophin signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
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INOH |
IL-7 signaling pathway
Toll-like receptor signaling pathway pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
EGF signaling pathway pathway
PDGF signaling pathway pathway
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PID NCI |
CD40/CD40L signaling
Ceramide signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Caspase Cascade in Apoptosis
TNF receptor signaling pathway
TRAIL signaling pathway
ErbB1 downstream signaling
RAC1 signaling pathway
BCR signaling pathway
JNK signaling in the CD4+ TCR pathway
CDC42 signaling events
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Fc-epsilon receptor I signaling in mast cells
IFN-gamma pathway
Osteopontin-mediated events
FAS (CD95) signaling pathway
p38 MAPK signaling pathway
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Cross-References | |||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
UniGene | Mm.15918 Mm.417168 Mm.468398 | ||||||||||||||||||||||||||||
RefSeq | NM_011945 XM_006517667 | ||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||
CCDS | CCDS26771 | ||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||