Version 5.4
Bos taurus Gene: BT.20328
Summary
InnateDB Gene IDBG-629047.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.20328
Gene Name PHD finger protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001634
Encoded Proteins
IDBP-680444
PHD finger protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112511:
This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:7528759-7534103
Strand Forward strand
Band
Transcripts
ENSBTAT00000002140 ENSBTAP00000002140
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035064 methylated histone binding
GO:0046872 metal ion binding
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0061086 negative regulation of histone H3-K27 methylation
GO:0061087 positive regulation of histone H3-K27 methylation
Cellular Component
GO:0005634 nucleus
GO:0035098 ESC/E(Z) complex
GO:0035861 site of double-strand break
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000112511
View Gene Order
ENSMUSG00000024193
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_71
Gene Expression pathway
REACT_222475
PRC2 methylates histones and DNA pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_233572
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BBS1
UniProt Splice Variant
Entrez Gene 508957
UniGene Bt.20328
RefSeq NM_001098914
HUGO HGNC:8919
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02054900
GenPept
RNA Seq Atlas 508957

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca