Version 5.4
Homo sapiens Gene: PHF1
Summary
InnateDB Gene IDBG-82785.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHF1
Gene Name PHD finger protein 1
Synonyms hPHF1; MTF2L2; PCL1; PHF2; TDRD19C
Species Homo sapiens
Ensembl Gene ENSG00000112511
Encoded Proteins
IDBP-82787
PHD finger protein 1
IDBP-82789
PHD finger protein 1
IDBP-375738
PHD finger protein 1
IDBP-375750
PHD finger protein 1
IDBP-375782
PHD finger protein 1
IDBP-589102
PHD finger protein 1
IDBP-807891
PHD finger protein 1
IDBP-597797
PHD finger protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:33410399-33416453
Strand Forward strand
Band p21.32
Transcripts
ENST00000374516 ENSP00000363640
ENST00000374512 ENSP00000363636
ENST00000427004 ENSP00000410494
ENST00000428274 ENSP00000392697
ENST00000427826 ENSP00000404788
ENST00000487667 ENSP00000432419
ENST00000459809 ENSP00000479423
ENST00000488767
ENST00000495509 ENSP00000434347
ENST00000486845
ENST00000479029
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035064 methylated histone binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0016568 chromatin modification
GO:0061086 negative regulation of histone H3-K27 methylation
GO:0061087 positive regulation of histone H3-K27 methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0035098 ESC/E(Z) complex
GO:0035861 site of double-strand break
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024193
View Gene Order
ENSBTAG00000001634
Not yet available
Pathways
NETPATH
REACTOME
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.166204
RefSeq NM_002636 NM_024165 XM_006715109
HUGO
OMIM
CCDS CCDS4777 CCDS4778
HPRD 04195
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca