InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.54851

Summary

InnateDB Gene

IDBG-629048.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.54851

Gene Name

inhibitor of nuclear factor kappa-B kinase subunit epsilon

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010408

Encoded Proteins

IDBP-680450

inhibitor of nuclear factor kappa-B kinase subunit epsilon

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21138416

[Mus musculus] Ikbke and other IKK kinases regulate each other by an intricate network involving phosphorylation of their catalytic and regulatory (NEMO, TANK) subunits to balance their activities during innate immunity.

PMID 21822257

[Mus musculus] Ikbke kinase modulates Il-17 signalling through Traf3ip2 adaptor protein phosphorylation, resulting in the induction of neutrophilia and pulmonary inflammation.

PMID 22065572

[Mus musculus] Ikbke is an important signalling molecule in the IFN pathway and is necessary to mount anti-viral immunity against West Nile virus.

PMID 22171011

[Mus musculus] Ikbke plays a critical role in regulating the balance between the type I and type II interferon (IFN) signalling pathways.

PMID 22532683

[Mus musculus] Ikbke is sequestered by arenavirus nucleoproteins to block its autocatalytic activity and its ability to active Irf3. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:4113295-4134772

Strand

Forward strand

Band

Transcripts

ENSBTAT00000013738

ENSBTAP00000013738

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 319 interaction(s) predicted by orthology.

Predicted by orthology
Total	319 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004704	NF-kappaB-inducing kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008384	IkappaB kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007252	I-kappaB phosphorylation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0038061	NIK/NF-kappaB signaling
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling