Mus musculus Gene: Ikbke | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-190983.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Ikbke | ||||||||||||||||||||||
Gene Name | inhibitor of kappaB kinase epsilon | ||||||||||||||||||||||
Synonyms | AW558201; IKK-i; IKKepsilon; Ikki | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000042349 | ||||||||||||||||||||||
Encoded Proteins |
inhibitor of kappaB kinase epsilon
inhibitor of kappaB kinase epsilon
inhibitor of kappaB kinase epsilon
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
Ikbke and other IKK kinases regulate each other by an intricate network involving phosphorylation of their catalytic and regulatory (NEMO, TANK) subunits to balance their activities during innate immunity.
Ikbke kinase modulates Il-17 signalling through Traf3ip2 adaptor protein phosphorylation, resulting in the induction of neutrophilia and pulmonary inflammation.
Ikbke is an important signalling molecule in the IFN pathway and is necessary to mount anti-viral immunity against West Nile virus.
Ikbke plays a critical role in regulating the balance between the type I and type II interferon (IFN) signalling pathways.
Ikbke is sequestered by arenavirus nucleoproteins to block its autocatalytic activity and its ability to active Irf3. (Demonstrated in human)
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 1:131254343-131279606 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | E4 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 333 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Toll Like Receptor 3 (TLR3) Cascade pathway
Innate Immune System pathway
Negative regulators of RIG-I/MDA5 signaling pathway
Immune System pathway
TRAF6 mediated IRF7 activation pathway
Toll-Like Receptors Cascades pathway
Activated TLR4 signalling pathway
MyD88-independent cascade pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TRAF3-dependent IRF activation pathway pathway
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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KEGG |
Toll-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Hepatitis C pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.386783 | ||||||||||||||||||||||
RefSeq | NM_019777 XM_006529761 XM_006529762 XM_006529764 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS15269 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||