InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ikbke

Summary

InnateDB Gene

IDBG-190983.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ikbke

Gene Name

inhibitor of kappaB kinase epsilon

Synonyms

AW558201; IKK-i; IKKepsilon; Ikki

Species

Mus musculus

Ensembl Gene

ENSMUSG00000042349

Encoded Proteins

IDBP-190985

inhibitor of kappaB kinase epsilon

IDBP-535823

inhibitor of kappaB kinase epsilon

IDBP-534146

inhibitor of kappaB kinase epsilon

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21138416

Ikbke and other IKK kinases regulate each other by an intricate network involving phosphorylation of their catalytic and regulatory (NEMO, TANK) subunits to balance their activities during innate immunity.

PMID 21822257

Ikbke kinase modulates Il-17 signalling through Traf3ip2 adaptor protein phosphorylation, resulting in the induction of neutrophilia and pulmonary inflammation.

PMID 22065572

Ikbke is an important signalling molecule in the IFN pathway and is necessary to mount anti-viral immunity against West Nile virus.

PMID 22171011

Ikbke plays a critical role in regulating the balance between the type I and type II interferon (IFN) signalling pathways.

PMID 22532683

Ikbke is sequestered by arenavirus nucleoproteins to block its autocatalytic activity and its ability to active Irf3. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:131254343-131279606

Strand

Reverse strand

Band

Transcripts

ENSMUST00000062108	ENSMUSP00000054126
ENSMUST00000162437
ENSMUST00000161764	ENSMUSP00000124190
ENSMUST00000160748
ENSMUST00000163029
ENSMUST00000162285
ENSMUST00000159195	ENSMUSP00000124486

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 333 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	333 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004704	NF-kappaB-inducing kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008384	IkappaB kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007252	I-kappaB phosphorylation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0038061	NIK/NF-kappaB signaling
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)