Version 5.4
Bos taurus Gene: SYNGAP1
Summary
InnateDB Gene IDBG-629070.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYNGAP1
Gene Name ras GTPase-activating protein SynGAP
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020975
Encoded Proteins
IDBP-680490
synaptic Ras GTPase activating protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197283:
The protein encoded by this gene is a major component of the postsynaptic density (PSD), a group of proteins found associated with NMDA receptors at synapses. The encoded protein is phosphorylated by calmodulin-dependent protein kinase II and dephosphorylated by NMDA receptor activation. Defects in this gene are a cause of mental retardation autosomal dominant type 5 (MRD5). [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:7537952-7566784
Strand Forward strand
Band
Transcripts
ENSBTAT00000027936 ENSBTAP00000027936
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005097 Rab GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0007389 pattern specification process
GO:0008542 visual learning
GO:0016358 dendrite development
GO:0032851 positive regulation of Rab GTPase activity
GO:0043113 receptor clustering
GO:0043408 regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0050771 negative regulation of axonogenesis
GO:0050803 regulation of synapse structure and activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0016020 membrane
GO:0043198 dendritic shaft
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000197283
View Gene Order
ENSMUSG00000067629
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
ras_pathway
Regulation of Ras family activation
Cross-References
SwissProt
TrEMBL F1MBI8
UniProt Splice Variant
Entrez Gene 790307
UniGene Bt.65817
RefSeq NM_001205466 XM_005223272 XM_005223273 XM_005223274 XM_005223275 XM_005223276 XM_005223277 XM_005223278 XM_005223279 XM_005223280 XM_005223281 XM_005223282
HUGO HGNC:11497
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02054900 DAAA02054901
GenPept
RNA Seq Atlas 790307

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca