InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Syngap1

Summary

InnateDB Gene

IDBG-156093.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syngap1

Gene Name

synaptic Ras GTPase activating protein 1 homolog (rat)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000067629

Encoded Proteins

IDBP-156095

synaptic Ras GTPase activating protein 1 homolog (rat)

IDBP-714372

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197283:
The protein encoded by this gene is a major component of the postsynaptic density (PSD), a group of proteins found associated with NMDA receptors at synapses. The encoded protein is phosphorylated by calmodulin-dependent protein kinase II and dephosphorylated by NMDA receptor activation. Defects in this gene are a cause of mental retardation autosomal dominant type 5 (MRD5). [provided by RefSeq, Dec 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:26941452-26970645

Strand

Forward strand

Band

A3.3

Transcripts

ENSMUST00000081285	ENSMUSP00000080038
ENSMUST00000177932	ENSMUSP00000137587

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding

Biological Process

GO:0007165	signal transduction
GO:0007265	Ras protein signal transduction
GO:0007389	pattern specification process
GO:0008542	visual learning
GO:0016358	dendrite development
GO:0032320	positive regulation of Ras GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:0043113	receptor clustering
GO:0043408	regulation of MAPK cascade
GO:0043524	negative regulation of neuron apoptotic process
GO:0046580	negative regulation of Ras protein signal transduction
GO:0048167	regulation of synaptic plasticity
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0050771	negative regulation of axonogenesis
GO:0050803	regulation of synapse structure and activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030054	cell junction
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane
GO:0043198	dendritic shaft
GO:0045202	synapse

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000197283

View Gene Order

ENSBTAG00000020975

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

ras_pathway

Regulation of Ras family activation

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.328888

RefSeq

NM_001281491 XM_006524235 XM_006524236 XM_006524238 XM_006524239 XM_006524240 XM_006524241 XM_006524242 XM_006524243 XM_006524244 XM_006524245 XM_006524246 XM_006524247

OMIM

CCDS

CCDS59625

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas