Version 5.4
Homo sapiens Gene: INPP4A
Summary
InnateDB Gene IDBG-62916.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INPP4A
Gene Name inositol polyphosphate-4-phosphatase, type I, 107kDa
Synonyms INPP4; TVAS1
Species Homo sapiens
Ensembl Gene ENSG00000040933
Encoded Proteins
IDBP-62920
inositol polyphosphate-4-phosphatase, type I, 107kDa
IDBP-295202
inositol polyphosphate-4-phosphatase, type I, 107kDa
IDBP-295196
inositol polyphosphate-4-phosphatase, type I, 107kDa
IDBP-295201
inositol polyphosphate-4-phosphatase, type I, 107kDa
IDBP-295129
inositol polyphosphate-4-phosphatase, type I, 107kDa
IDBP-478619
inositol polyphosphate-4-phosphatase, type I, 107kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:98444854-98594390
Strand Forward strand
Band q11.2
Transcripts
ENST00000074304 ENSP00000074304
ENST00000409016 ENSP00000386704
ENST00000409463 ENSP00000386329
ENST00000409851 ENSP00000386777
ENST00000409540 ENSP00000387294
ENST00000463367
ENST00000523221 ENSP00000427722
ENST00000468638
ENST00000467042
ENST00000498026
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007165 signal transduction
GO:0016311 dephosphorylation
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026113
View Gene Order
ENSBTAG00000004814
Not yet available
Pathways
NETPATH
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_120756
Synthesis of PIPs at the early endosome membrane pathway
REACT_150352
Synthesis of IP2, IP, and Ins in the cytosol pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt Q96PE3
TrEMBL B8ZZB2 D3DVH3
UniProt Splice Variant
Entrez Gene 3631
UniGene Hs.469386 Hs.660836
RefSeq NM_001134224 NM_001134225 NM_001566 NM_004027 XM_006712503 XM_006712504 XM_006712507 XM_006712508 XM_006712509
HUGO HGNC:6074
OMIM 600916
CCDS CCDS46369 CCDS46370 CCDS46371 CCDS46372
HPRD
IMGT
EMBL AC010134 AF368319 BC028361 CH471127 U26398 U96919
GenPept AAB01068 AAB72150 AAH28361 AAK58870 AAX93230 EAX01906 EAX01907
RNA Seq Atlas 3631

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca