InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INPP4A

Summary

InnateDB Protein

IDBP-295201.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INPP4A

Protein Name

inositol polyphosphate-4-phosphatase, type I, 107kDa

Synonyms

INPP4; TVAS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000386777

InnateDB Gene

IDBG-62916 (INPP4A)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 3,4-bisphosphate.

Subcellular Localization

Disease Associations

Tissue Specificity

Isoform 1 is expressed in the platelets, MEG- 01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain. {ECO:0000269PubMed:11485317}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO:0034597	phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0007165	signal transduction
GO:0016311	dephosphorylation
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process