InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BAG4

Summary

InnateDB Gene

IDBG-629178.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAG4

Gene Name

BAG family molecular chaperone regulator 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013143

Encoded Proteins

IDBP-680571

BAG family molecular chaperone regulator 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156735:
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 27:33051377-33097830

Strand

Forward strand

Band

Transcripts

ENSBTAT00000017468

ENSBTAP00000017468

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0051087	chaperone binding

Biological Process

GO:0010763	positive regulation of fibroblast migration
GO:0030838	positive regulation of actin filament polymerization
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0045785	positive regulation of cell adhesion
GO:0051496	positive regulation of stress fiber assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0071356	cellular response to tumor necrosis factor
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0072659	protein localization to plasma membrane
GO:0097178	ruffle assembly
GO:2001145	negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005886	plasma membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000156735

View Gene Order

ENSMUSG00000037316

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

ceramide_pathway

Ceramide signaling pathway

tnfpathway

TNF receptor signaling pathway

hivnefpathway

HIV-1 Nef: Negative effector of Fas and TNF-alpha

Cross-References

SwissProt

TrEMBL

F1MSS9 Q1JPF8

UniProt Splice Variant

Entrez Gene

516353

UniGene

Bt.27376

RefSeq

NM_001110532

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BT025395 BT030482 DAAA02060846 DAAA02060847 DAAA02060848

GenPept

ABF57351 ABQ12922

RNA Seq Atlas

516353