Version 5.4
Bos taurus Gene: BT.31874
Summary
InnateDB Gene IDBG-629190.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.31874
Gene Name histone-lysine N-methyltransferase SETDB2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007329
Encoded Proteins
IDBP-680589
histone-lysine N-methyltransferase SETDB2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136169:
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:19111394-19147324
Strand Forward strand
Band
Transcripts
ENSBTAT00000009641 ENSBTAP00000009641
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0018024 histone-lysine N-methyltransferase activity
GO:0046974 histone methyltransferase activity (H3-K9 specific)
Biological Process
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0032259 methylation
GO:0034968 histone lysine methylation
GO:0051567 histone H3-K9 methylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000136169
View Gene Order
ENSMUSG00000071350
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
mmu00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MXG0
UniProt Splice Variant
Entrez Gene 509382
UniGene Bt.31874
RefSeq NM_001143861 XM_005213599 XM_005213600 XM_005213601 XM_005213602 XM_005213603
HUGO HGNC:20263
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02032913 DAAA02032914
GenPept
RNA Seq Atlas 509382

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca