Version 5.4
Mus musculus Gene: Setdb2
Summary
InnateDB Gene IDBG-169918.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Setdb2
Gene Name SET domain, bifurcated 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000071350
Encoded Proteins
IDBP-169920
SET domain, bifurcated 2
IDBP-258533
SET domain, bifurcated 2
IDBP-531612
SET domain, bifurcated 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136169:
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:59402009-59440884
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000095775 ENSMUSP00000093450
ENSMUST00000111253 ENSMUSP00000106884
ENSMUST00000161459 ENSMUSP00000124696
ENSMUST00000159640
ENSMUST00000160904
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 0
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0046974 histone methyltransferase activity (H3-K9 specific)
Biological Process
GO:0001947 heart looping
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0034968 histone lysine methylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051567 histone H3-K9 methylation
GO:0070986 left/right axis specification
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000136169
View Gene Order
ENSBTAG00000007329
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00310
Lysine degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.205022
RefSeq NM_001081024
OMIM
CCDS CCDS36939
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca