InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.27994

Summary

InnateDB Gene

IDBG-629231.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.27994

Gene Name

aminopeptidase N

Synonyms

APN; CD13; P150

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016881

Encoded Proteins

IDBP-680637

aminopeptidase N

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25801433

[Mus musculus] Lipopolysaccharide-mediated myeloid Anpep (CD13) expression governs internalization of Tlr4 and negatively regulates Tlr4 signalling, thereby balancing the innate response by maintaining the inflammatory equilibrium critical to innate immune regulation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166825:
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:21620139-21637144

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022456

ENSBTAP00000022456

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005615	extracellular space
GO:0005765	lysosomal membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0009897	external side of plasma membrane
GO:0070062	extracellular vesicular exosome