Version 5.4
Homo sapiens Gene: ANPEP
Summary
InnateDB Gene IDBG-29618.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANPEP
Gene Name alanyl (membrane) aminopeptidase
Synonyms APN; CD13; GP150; LAP1; P150; PEPN
Species Homo sapiens
Ensembl Gene ENSG00000166825
Encoded Proteins
IDBP-29620
alanyl (membrane) aminopeptidase
IDBP-584041
alanyl (membrane) aminopeptidase
IDBP-598160
alanyl (membrane) aminopeptidase
IDBP-600021
alanyl (membrane) aminopeptidase
IDBP-592024
alanyl (membrane) aminopeptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25801433
[Mus musculus] Lipopolysaccharide-mediated myeloid Anpep (CD13) expression governs internalization of Tlr4 and negatively regulates Tlr4 signalling, thereby balancing the innate response by maintaining the inflammatory equilibrium critical to innate immune regulation.
Entrez Gene
Summary Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:89784889-89815401
Strand Reverse strand
Band q26.1
Transcripts
ENST00000300060 ENSP00000300060
ENST00000558740
ENST00000559761
ENST00000558177
ENST00000560030 ENSP00000453545
ENST00000559887
ENST00000560028 ENSP00000453405
ENST00000559874 ENSP00000452934
ENST00000560137 ENSP00000453413
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001618 virus receptor activity
GO:0004177 aminopeptidase activity
GO:0004872 receptor activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0001525 angiogenesis
GO:0002003 angiotensin maturation
GO:0006508 proteolysis
GO:0009615 response to virus
GO:0016032 viral process
GO:0030154 cell differentiation
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005765 lysosomal membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005829 cytosol
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039062
View Gene Order
ENSBTAG00000016881
Not yet available
Pathways
NETPATH
REACTOME
REACT_147707
Metabolism of Angiotensinogen to Angiotensins pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa04614
Renin-angiotensin system pathway
hsa04640
Hematopoietic cell lineage pathway
hsa00480
Glutathione metabolism pathway
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
Cross-References
SwissProt
TrEMBL H0YMC1
UniProt Splice Variant
Entrez Gene 290
UniGene Hs.1239
RefSeq NM_001150 XM_005254892
HUGO HGNC:500
OMIM 151530
CCDS CCDS10356
HPRD 01055
IMGT
EMBL AC018988 AC079075
GenPept
RNA Seq Atlas 290

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca