Bos taurus Gene: CLCN3 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-629261.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | CLCN3 | ||||||||||||||
Gene Name | H(+)/Cl(-) exchange transporter 3 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000020130 | ||||||||||||||
Encoded Proteins |
chloride channel 3
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109572:
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 8:1426804-1502615 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
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Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Stimuli-sensing channels pathway
Transmembrane transport of small molecules pathway
Ion channel transport pathway
Stimuli-sensing channels pathway
Ion channel transport pathway
Transmembrane transport of small molecules pathway
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KEGG | |||||||||||||||
INOH | |||||||||||||||
PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | F1N299 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 522719 | ||||||||||||||
UniGene | Bt.63034 | ||||||||||||||
RefSeq | NM_001193003 XM_005209791 XM_005209792 XM_005209793 XM_005209794 | ||||||||||||||
HUGO | HGNC:2021 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | DAAA02021754 DAAA02021755 | ||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | 522719 | ||||||||||||||