Version 5.4
Homo sapiens Gene: CLCN3
Summary
InnateDB Gene IDBG-44331.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLCN3
Gene Name chloride channel, voltage-sensitive 3
Synonyms ClC-3; CLC3
Species Homo sapiens
Ensembl Gene ENSG00000109572
Encoded Proteins
IDBP-44333
chloride channel 3
IDBP-44335
chloride channel 3
IDBP-482053
chloride channel 3
IDBP-478187
chloride channel 3
IDBP-479801
chloride channel 3
IDBP-473593
chloride channel 3
IDBP-477851
chloride channel 3
IDBP-481816
chloride channel 3
IDBP-812883
chloride channel, voltage-sensitive 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:169612633-169723673
Strand Forward strand
Band q33
Transcripts
ENST00000347613 ENSP00000261514
ENST00000360642 ENSP00000353857
ENST00000504131 ENSP00000424540
ENST00000511092 ENSP00000425160
ENST00000513761 ENSP00000424603
ENST00000512813 ENSP00000425823
ENST00000506924
ENST00000507875 ENSP00000425323
ENST00000502998
ENST00000515420 ENSP00000422678
ENST00000613795 ENSP00000478336
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 7 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015297 antiporter activity
GO:0030165 PDZ domain binding
GO:0030554 adenyl nucleotide binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0006885 regulation of pH
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0048388 endosomal lumen acidification
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030658 transport vesicle membrane
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004319
View Gene Order
ENSBTAG00000020130
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.481186 Hs.595439 Hs.717491
RefSeq NM_001243372 NM_001243374 NM_001829 NM_173872
HUGO
OMIM
CCDS CCDS34100 CCDS34101 CCDS58932 CCDS75208
HPRD 02785
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca