InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MTMR2

Summary

InnateDB Gene

IDBG-629316.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTMR2

Gene Name

Myotubularin-related protein 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016557

Encoded Proteins

IDBP-680732

Myotubularin-related protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087053:
This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:14640226-14707505

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022028

ENSBTAP00000022028

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0042803	protein homodimerization activity
GO:0052866	phosphatidylinositol phosphate phosphatase activity

Biological Process

GO:0016311	dephosphorylation
GO:0031642	negative regulation of myelination
GO:0032288	myelin assembly
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0046488	phosphatidylinositol metabolic process
GO:0046855	inositol phosphate dephosphorylation
GO:0046856	phosphatidylinositol dephosphorylation
GO:0048666	neuron development
GO:0051262	protein tetramerization