InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MTMR2

Summary

InnateDB Protein

IDBP-680732.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MTMR2

Protein Name

Myotubularin-related protein 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000022028

InnateDB Gene

IDBG-629316 (MTMR2)

Protein Structure

UniProt Annotation

Function

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note=Partly associated with membranes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0042803	protein homodimerization activity
GO:0052866	phosphatidylinositol phosphate phosphatase activity

Biological Process

GO:0016311	dephosphorylation
GO:0031642	negative regulation of myelination
GO:0032288	myelin assembly
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0046488	phosphatidylinositol metabolic process
GO:0046855	inositol phosphate dephosphorylation
GO:0046856	phosphatidylinositol dephosphorylation
GO:0048666	neuron development
GO:0051262	protein tetramerization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005774	vacuolar membrane
GO:0016020	membrane
GO:0031901	early endosome membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR004182 GRAM domain
IPR010569 Myotubularin-like phosphatase domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF02893
PF06602

PRINTS

PIRSF

SMART

SM00404
SM00568

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A6QLT2