InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SRSF1

Summary

InnateDB Gene

IDBG-629320.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRSF1

Gene Name

Serine/arginine-rich splicing factor 1

Synonyms

SFRS1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014766

Encoded Proteins

IDBP-680727

Serine/arginine-rich splicing factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136450:
This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13. [provided by RefSeq, Sep 2010]
This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:9038200-9041927

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000049486

ENSBTAP00000046374

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 130 interaction(s) predicted by orthology.

Predicted by orthology
Total	130 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0050733	RS domain binding

Biological Process

GO:0000395	mRNA 5'-splice site recognition
GO:0001701	in utero embryonic development
GO:0006397	mRNA processing
GO:0006810	transport
GO:0008380	RNA splicing
GO:0051028	mRNA transport
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0016607	nuclear speck
GO:0035145	exon-exon junction complex
GO:0070062	extracellular vesicular exosome
GO:0071013	catalytic step 2 spliceosome